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. 2018 Sep 27;66(11):2414–2426. doi: 10.1002/glia.23480

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© 2018 The Authors. GLIA Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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cAMP in astrocytes affects wound closure in the scratch assay. (a) A scratch wound was created in astrocyte monolayers cultured in FBS‐containing media or PDM supplemented with 100 nM TX14(A). Drugs were added and dynamics of the wound closure was monitored for 72 hr (n = 5, triplicates). (b) DAPI staining of astrocytes shows that NKH477 (10 μM), 6‐BenZ‐cAMP (500 μM), and 8‐pCPT‐2′‐O‐Me‐cAMP (1,000 μM) significantly decreased cell numbers as compared to control (n = 4, triplicates). In both cases, one‐way ANOVA with Dunnett's post hoc analysis. **p < .01, ***p < .001 vs. control [Color figure can be viewed at wileyonlinelibrary.com]