MEDICAL SCIENCES. For the article “Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia,” by James M. Allan, Christopher P. Wild, Sara Rollinson, Eleanor V. Willett, Anthony V. Moorman, Gareth J. Dovey, Philippa L. Roddam, Eve Roman, Raymond A. Cartwright, and Gareth J. Morgan, which appeared in number 20, September 25, 2001, of Proc. Natl. Acad. Sci. USA (98, 11592-11597; First Published September 11, 2001; 10.1073/pnas.191211198), due to a printer's error, some column headings in Table 3 were shifted to the left. The corrected table appears below.
Table 3.
GST geotype and the risk of developing t-AML by type of previous therapy
Variable | De novo AMLn (%) | t-AML
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|
Total t-AML
cases
|
Radiotherapy
|
Chemotherapy
|
||||||||
n (%) | OR | 95% CI | n (%) | OR | 95% CI | n (%) | OR | 95% CI | ||
GSTM1* | ||||||||||
Carriers | 188 (45) | 40 (45) | 1 | — | 15 (39) | 1 | — | 25 (49) | 1 | — |
Null | 229 (55) | 49 (55) | 0.99 | 0.62–1.60 | 23 (61) | 1.25 | 0.61–2.60 | 26 (51) | 0.85 | 0.48–1.53 |
SNA | 3 | 0 | 0 | 0 | ||||||
GSTT1* | ||||||||||
Carriers | 338 (81) | 70 (79) | 1 | — | 33 (87) | 1 | — | 37 (73) | 1 | — |
Null | 79 (19) | 19 (21) | 1.19 | 0.67–2.13 | 5 (13) | 0.66 | 0.26–1.84 | 14 (27) | 1.61 | 0.83–3.14 |
SNA | 3 | 0 | 0 | 0 | ||||||
GSTP1† | ||||||||||
Ile/Ile | 202 (49) | 33 (37) | 1 | — | 19 (50) | 1 | — | 14 (27) | 1 | — |
Ile/Val | 151 (36) | 40 (45) | 1.87 | 1.11–3.17 | 12 (32) | 0.94 | 0.42–2.12 | 28 (55) | 2.87 | 1.45–5.67 |
Val/Val | 61 (15) | 16 (18) | 1.67 | 0.84–3.30 | 7 (18) | 1.16 | 0.43–3.13 | 9 (18) | 2.17 | 0.89–5.29 |
SNA | 6 | 0 | 0 | 0 | ||||||
GSTP1† | ||||||||||
Ile/Ile | 202 (49) | 33 (37) | 1 | — | 19 (50) | 1 | — | 14 (27) | 1 | — |
Ile/Val + Val/Val | 212 (51) | 56 (63) | 1.81 | 1.11–2.94 | 19 (50) | 1.01 | 0.50–2.07 | 37 (73) | 2.66 | 1.39–5.09 |
SNA | 6 | 0 | 0 | 0 |
ORs and 95% CIs were estimated relative to de novo AML cases for an unmatched analysis adjusted for age and sex. SNA, sample not amplifiable.
Carriers of at least one intact allele are used as reference.
Isoleucine homozygotes (Ile/Ile) are used as reference.