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. 2001 Dec 11;98(26):15393.

Correction

PMCID: PMC64922

MEDICAL SCIENCES. For the article “Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia,” by James M. Allan, Christopher P. Wild, Sara Rollinson, Eleanor V. Willett, Anthony V. Moorman, Gareth J. Dovey, Philippa L. Roddam, Eve Roman, Raymond A. Cartwright, and Gareth J. Morgan, which appeared in number 20, September 25, 2001, of Proc. Natl. Acad. Sci. USA (98, 11592-11597; First Published September 11, 2001; 10.1073/pnas.191211198), due to a printer's error, some column headings in Table 3 were shifted to the left. The corrected table appears below.

Table 3.

GST geotype and the risk of developing t-AML by type of previous therapy

Variable De novo AMLn (%) t-AML
Total t-AML cases
Radiotherapy
Chemotherapy
n (%) OR 95% CI n (%) OR 95% CI n (%) OR 95% CI
GSTM1*
 Carriers 188 (45) 40 (45) 1 15 (39) 1 25 (49) 1
 Null 229 (55) 49 (55) 0.99 0.62–1.60 23 (61) 1.25 0.61–2.60 26 (51) 0.85 0.48–1.53
 SNA 3 0 0 0
GSTT1*
 Carriers 338 (81) 70 (79) 1 33 (87) 1 37 (73) 1
 Null 79 (19) 19 (21) 1.19 0.67–2.13 5 (13) 0.66 0.26–1.84 14 (27) 1.61 0.83–3.14
 SNA 3 0 0 0
GSTP1
 Ile/Ile 202 (49) 33 (37) 1 19 (50) 1 14 (27) 1
 Ile/Val 151 (36) 40 (45) 1.87 1.11–3.17 12 (32) 0.94 0.42–2.12 28 (55) 2.87 1.45–5.67
 Val/Val 61 (15) 16 (18) 1.67 0.84–3.30 7 (18) 1.16 0.43–3.13 9 (18) 2.17 0.89–5.29
 SNA 6 0 0 0
GSTP1
 Ile/Ile 202 (49) 33 (37) 1 19 (50) 1 14 (27) 1
 Ile/Val + Val/Val 212 (51) 56 (63) 1.81 1.11–2.94 19 (50) 1.01 0.50–2.07 37 (73) 2.66 1.39–5.09
 SNA 6 0 0 0

ORs and 95% CIs were estimated relative to de novo AML cases for an unmatched analysis adjusted for age and sex. SNA, sample not amplifiable. 

*

Carriers of at least one intact allele are used as reference. 

Isoleucine homozygotes (Ile/Ile) are used as reference. 


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