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. Author manuscript; available in PMC: 2020 Mar 7.
Published in final edited form as: Cell. 2019 Feb 11;176(6):1490–1501.e12. doi: 10.1016/j.cell.2019.02.002

Figure 1: Structures Dot1L bound to H2B-ubiquitin nucleosome.

Figure 1:

A, Cryo-EM reconstruction of the 2-to-1 active state complex. B, Cryo-EM reconstruction of the poised state complex. C, Atomic model of the active state complex between Dot1L and the H2B-Ub nucleosome. The H4 tail, H3K79Nle and the acidic patch are depicted as spheres and the SAM cofactor is depicted in stick representation. See also Figures S1–S4.