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U4-cs1-suppressors in Brr2 cluster together in its N-terminal PWI domain. The U4-cs1-suppressor sites in Brr2’s PWI domain (yellow spheres) face, but do not contact, its catalytic N-terminal helicase domain and regulatory C-terminal helicase domain. Linkers that join the PWI domain to the rest of Brr2 are disordered; dotted lines indicate the connectivity. The structure is from Absmeier et al. (2017) (PDB: 5m52).
