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. 2019 Mar 21;212(1):111–124. doi: 10.1534/genetics.119.301922

Figure 7.

Figure 7

A subset of U4-cs1-suppressors in Prp8 colocalize with Prp28 in the human tri-snRNP. The two RecA domains of human (h) Prp28 (gray) contact residues in Prp8 that, when mutated in yeast, suppress the cold sensitivity of prp28-1 (green) or U4-cs1 (yellow) strains. Parts of the hPrp8 NTD1 and linker/endonuclease-like (linker/endo) domains are shown, and residues are indicated with yeast (y) numbering. The N-terminal 351 residues of hPrp28 are not modeled, but the C-terminal end of the Prp28-NTD (labeled) is adjacent to prp28-1-suppressor substitutions in Prp8. Model coordinates were kindly provided by Holger Stark and Reinhard Lührmann.