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Several U4-cs1-suppressor substitutions in Prp8 map to a potential IP6-binding site. The model shown is of the yeast C* spliceosome (Fica et al. 2017; PDB: 5mq0). Prp8 is lavender with U4-cs1-suppressor sites in yellow. The inositol group is green and the attached phosphates are orange and red. Modeled distances between atoms indicated by yellow dotted lines are in Ångstroms and are consistent with hydrogen bonds.
