Table 4. Genes related to JNK signaling.

Gene	Role	Reference
JNK pathway/regulators
Jra	Jun transcription factor, essential part of JNK pathway. Also a JNK target gene.	Ríos-Barrera and Riesgo-Escovar (2013)
puc	Protein phosphatase that is a feedback-negative regulator of JNK. JNK target gene.	Ríos-Barrera and Riesgo-Escovar (2013)
Gadd45	Mammalian relatives are JNK activators. Fly protein genetically interacts with hep = Fly JNKK.	Peretz et al. (2007)
Pvf1	PDGF- and VEGF-related factor 1. Involved in corpse removal, a role in which it and its receptor Pvr are upstream of JNK.	Ishimaru et al. (2004)
Pvf2	PDGF- and VEGF-related factor 2. Activated by IMD pathway in a JNK-dependent way and acts with Pvf3 in turn as a feedback-negative regulator of JNK signaling.	Bond and Foley (2009)
scaf	Inactive serine protease. JNK target gene and feedback-negative regulator of the JNK pathway.	Rousset et al. (2010)
Traf4	TNF receptor-associated factor 4. Traf2 regulates oxidative stress with Atg9 through the JNK pathway.	Tang et al. (2013), Ríos-Barrera and Riesgo-Escovar (2013)
JNK target genes
ImpL2	Secreted insulin/IGF antagonist .	Jasper et al. (2001)
Ilp8	Divergent member of the insulin/IGF/relaxin-like family.	La Fortezza et al. (2016)
Myo61F	Myo1C. Induction by LPS requires JNK.	Silverman et al. (2003)
Nlaz	Neural lazarillo. A lipocalin involved in metabolic homeostasis.	Hull-Thompson et al. (2009), Kučerová et al. (2016)
scb	Integrin α-chain.	Homsy et al. (2006)
upd2	Unpaired 2. JAK-STAT ligand.	Pastor-Pareja et al. (2008)
upd3	Unpaired 3. JAK-STAT ligand.	Santabárbara-Ruiz (2015), Pastor-Pareja et al. (2008)
MMP1	Matrix metalloproteinase 1.	Uhlirova and Bohmann (2006)

List of genes that were upregulated in both sas-4 and asl mutants relative to WT, and are either components or the JNK signaling cascade or transcriptional targets of JNK signaling. IMD, immune deficiency; TNF, tumor necrosis factor; IGF, insulin-like growth factor; LPS, lipopolysaccharide.