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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Pain. 2019 May;160(Suppl 1):S1–S10. doi: 10.1097/j.pain.0000000000001540

Table 2. Some of the risk factors associated with an increased risk of developing CIPN.

Risk factor Comments Reference
Older age May be due to lower chance of recovery from acute CIPN [17; 78]
Medication: cardiovascular especially beta blockers Opportunity to modify medication prior to starting chemotherapy. [85]
Co-morbid health conditions Those where there may be associated increased risk of neuropathy e.g. diabetes, HIV, excess alcohol, smoking; decreased creatinine clearance [28; 88]
Raised Body Mass Index (BMI) Potential mechanism not well understood, but may be related to pro-inflammatory state associated with obesity
Low serum albumin May reflect lower general health status [40] [54; 82]
Use of opioids Prolonged use more likely in patients with CIPN. Need further work to understand if this is due to pain severity, or to a mechanistic interaction with opioids increasing CIPN risk (OR 2.0, 1.06-3.69) [91]