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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1990 Jun-Jul;81(6-7):554–556. doi: 10.1111/j.1349-7006.1990.tb02606.x

Acquired Expression of hst‐1 in an Autonomous Subline (Chiba Subline 2) Derived from Androgen‐responsive Mouse Mammary Tumor (Shionogi Carcinoma 115)

Koichiro Akakura 1, Yuzo Furuya 1, Naohide Sato 1, Takaomi Kodama 1, Shinichi Teshima 2, Yukio Shimosato 2, Teruhiko Yoshida 3, Masaaki Terada 3, Jun Shimazaki 1,✉
PMCID: PMC6504066  PMID: 1976117

Abstract

Since growth of Shionogi Carcinoma 115 (SC 115) and its autonomous subline (CS 2) were regulated by fibroblast growth factor‐like peptide, expression of int‐2 and hst‐1 was examined in these cell lines. Hybridization of genomic DNA with long terminal repeat of mouse mammary tumor virus (MMTV) revealed the same pattern of restriction fragments, showing the same integration of MMTV. Although weak expression of int‐2 was noticed in the two cells, clear expression of hst‐1 was seen only in CS 2 cultured with/without testosterone. It is suggested that autonomous growth of androgen‐unresponsive CS 2 is connected with expression of hst‐1.

Keywords: Shionogi Carcinoma 115, Chiba Subline 2, int‐2, hst‐1

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