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. 2019 Apr 12;10(28):2755–2787. doi: 10.18632/oncotarget.26763

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Copyright: © 2019 Madugula et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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MEF-2 is also activated by PI3K/AKT pathway which activates mTOR as a downstream target and also increases the transcription of MyoD and MEF-2 along with other transcription factors. The receptor tyrosine kinase (RTK) under specific stimulus activates various different transcription factors of AP-1 family like c-JUN and FOS and aids in the activation of MEF-2 via the MAPK family of MEK/ERK.