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. Author manuscript; available in PMC: 2020 Mar 19.
Published in final edited form as: Immunity. 2019 Mar 19;50(3):655–667.e4. doi: 10.1016/j.immuni.2019.02.013

Figure 1. Regulatory T cells facilitate epidermal regeneration after injury.

Figure 1

(a) Schematic showing diphtheria toxin (DT) administration schedule after skin barrier disruption. Cntrl animals are DT-treated WT mice or FoxP3DTR littermates not given DT.

(b) Transepidermal water loss (TEWL) on the indicated days of recovery.

(c) qRT-PCR of epidermal differentiation genes normalized to β2m during barrier regeneration from the back affected back skin of Cntrl and Treg cell-depleted mice.

(d) Representative histology 2 days after barrier injury and

(e) quantification of epidermal thickness of affected back skin of Cntrl and Treg cell-depleted mice throughout the course of barrier repair. Results in b are representative of > 10 experiments (n=2–4 mice per group). Results in d & e are representative of 3 experiments (n = 3 mice per group) Scale bar in d is 50 μm. See also Supplementary Figures 1 and 2.