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. 2019 Apr 9;92(15):e1724–e1738. doi: 10.1212/WNL.0000000000007262

Figure 1. Absolute lymphocyte counts (ALCs) over 8 years of dimethyl fumarate (DMF) treatment and lymphocyte subsets by ALC categories.

Figure 1

(A) ALCs over 8 years of DMF treatment. Mean (± SE) and 95% confidence intervals (CIs) are presented (n = 2,470). Lower limit of normal (LLN) (0.91 × 109/L) is signified by the dotted line. aData not presented for <10 patients. (B) Lymphocyte subsets by ALC categories CD4+ LLN = 0.2 × 109/L; CD8+ LLN = 0.1 × 109/L. Median (values inside the bars) and 95% CIs are presented. Data were stratified by all ALCs collected during the study (ALC 0.5 to <0.8 × 109/L for ≥6 months [moderate, prolonged lymphopenia]; ALC <0.5 × 109/L for ≥6 months [severe, prolonged lymphopenia]; ALC always ≥0.91 × 109/L [always ≥ LLN]). Patients were categorized as having moderate to severe prolonged lymphopenia if they met these criteria at any time during the study. NK = natural killer.