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Ribbon representation of ALTHEA Gold Library™ scaffolds. The two scaffolds offer different topographies at the antigen-binding site. Left: scaffold 3-20/3-23 (PDB ID: 5I1c)18 has a short L1 loop creating a flat paratope favorable to protein epitopes. Right: scaffold 4-01/3-23 (PDB ID: 5I1d)18 has a long CDR-L1 loop (L1) creating a groove suitable for peptide binding.
