Figure 5.

Sites on rituximab that undergo significant (a) increases and (b) decreases in DEPC modification after heat stress at 65°C for 4 hr, as compared to non-stressed rituximab. Spheres represent residues that undergo significant changes in label levels (p < 0.05). Red represents labeling increases while blue represents decreases. Note that, for clarity, only one asymmetric unit of rituximab structure is labeled in this figure. (See Figure 3 for more details about rituximab’s molecular model.).