Textbook of Nephro-Endocrinology, 2nd edition, is a translational reference in the field of nephro-endocrinology. Conceived as a continuation of Michael Dunn’s Nephro-Endocrinology from 1983, the current textbook reflects the global development of molecular biology and translational medicine concepts, in the spirit of evidence based medicine. Along 31 chapters, the reader can find classical and new data about relationship between kidney function and the endocrine (RAA) system. In the first chapter, the renin-angiotensin-aldosterone system is detailed, including receptors for each of the components. Then, in the following 3 chapters, the RAA system is considered in relationship with the kidneys, heart and RAA pharmacologic aspects. However, the molecular biology of its components is detailed in other chapters as well, along the book. Chapters 5-8 are dedicated to vasopressin, its molecular biology and pharmacologic aspects, including diabetes insipidus. The natriuretic peptides are also considered in an integrated translational approach from basic science to clinical aspects.
Further aspects are related to hematology, from erythropoietin to clinical aspects of erythropoietin analogs and extrahematopoetic actions. Of course, metabolic syndrome could not be left aside, as an expanding heath problem of the modern societies. Then a chapter is dedicated to growth hormone and others are related to sexual dysfunctions in chronic kidney disease. Vitamin D and phosphate/calcium metabolism are also subject to intense translational research and therefore are presented in several chapters of this interesting textbook. Finally, thyroid is also considered in the framework of chronic kidney disease patients.
Altogether, the book is investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers both researchers and clinicians new information about the treatment of kidney-related diseases such as anemia, rickets, hypoparathyroidism and osteoporosis. The topics are divided into hormones produced by the kidneys and hormones that act on the kidney. The current textbook has also a section on hormonal disturbances in individuals with chronic renal insufficiency.
Changes to this edition include new chapters focused on chronic kidney disease, hypercalcemia/hypocalcemia and the interaction of dialysis, new molecular biology data from historical perspectives. All chapters include preclinical data, tables and schemas that help the practitioner to translate this data into clinical recommendations. There are dedicated chapters for insulin/diabetes, growth hormone, sex steroids, thyroid hormones, acid–base disturbances, and pregnancy.