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. 2018 Nov 22;104(5):973–985. doi: 10.3324/haematol.2018.199661

Figure 3.

Figure 3.

AC-73 has no significant effect on cell growth, differentiation and cell cycle progression in normal granulocytic (G) and monocytic (Mo) differentiating hematopoietic progenitor cells (HPCs). (A) Cell growth analysis during G and Mo differentiation of HPCs, in presence of AC-73 used at 5 μM and added every 2 days in cultures, as compared to control (C) cells. (B) Cell cycle analysis at day 7 of G and Mo differentiation of HPCs treated with AC-73 (5 μM), as compared to control HPCs. (C) Phenotype analysis performed by analyzing CD11b, CD15 and CD14 expression levels in G and Mo differentiating HPCs at day 15, in the presence or not (C) of AC-73. (A-C) Mean±Standard Error of Mean (SEM) of three independent experiments is shown. *P<0.05; ns: not significant. (D) Morphological analysis at day 7 of the differentiation and maturation of G and Mo differentiating HPCs treated with AC-73, as compared to control (C) HPCs, and stained with May-Grünwald-Giemsa. (D) One representative experiment out of three is shown.