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. 2019 May;104(5):e229. doi: 10.3324/haematol.2019.220533

GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells

Beibei Zhang 1,2,3, Pilar Ayuda-Durán 1,2,3, Laure Piechaczyk 1,2,4, Yngvar Fløisand 1,2,5, Mireia Mayoral Safont 6, Ida Tveit Karlsen 6, Zina Fandalyuk 6, Dagim Tadele 1,2,4, Pepijn van Mierlo 1, Alexander D Rowe 7, Joseph M Robertson 1,2, Bjørn Tore Gjertsen 5,8, Emmet McCormack 5,8, Jorrit M Enserink 1,2,9,
PMCID: PMC6518908  PMID: 31040234

Our paper reported that FLT3-ITD-positive AML cells are addicted to HSP90 activity, and that the HSP90 family member GRP94 is required for aberrant endoplasmic reticulum retention of FLT3-ITD. We have reason to question the provenance of the data shown in Figures 2E, 2F, 2G, 2H, 4A, 4C, 5D, 5E, S2A, S2D, S2E, S3B, S3F, S4E, S4F and S4I, as well as the zebrafish images shown in Figure 7, all of which were prepared by the first author of the article. The figures provided by all other authors are not in question. While we believe the overall conclusions of our manuscript remain intact, the most appropriate course of action is to retract the paper. All authors have agreed to this Retraction. We deeply regret this circumstance and apologize to the scientific community for the inconvenience that this may have caused.


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