Figure 5.
Effects of altered buffer power. A, Abolition of centripetal propagation of the Ca2+ transient by rapid atrial pacing (RAP). Upper traces are linescan images. Lower records show [Ca2+]i measured at surface of cell (black) and in center (green). Left, Records from control. Right, Records after rapid stimulation. Reproduced from.71 B, Relaxation of contraction in isolated rat myocytes. Records show control (euthyroid), hypothyroid, and hypothyroid with parvalbumin expressed by gene transfer. Reproduced from.72 C, Left, comparison of the effects of the I79N mutation of troponin T with that of the Ca2+ sensitizing agent EMD 57033 on the relationship between pCa and force. Right, Effects of EMD 57033 on the occurrence of ventricular tachycardia (VT). Reproduced from Greiser et al.73