Table 2.
The percentage differences in AUCs of postprandial plasma metabolite levels after NC-meal and HC-meal intake in the PROX1 high-risk-genotype (CC) men compared to the low-risk genotype carriers (CT/TT).
| Name | Molecular Weight, Da | RT, Min | NC-Meal | HC-Meal | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Change, % | p-Value | p (corr) | VIP | Change, % | p-Value | p (corr) | VIP | |||
| PE 38:6 | 763.5152 | 9.40 | 50 | 0.25 | 0.43 | 1.38 | 62 | 0.18 | −0.56 | 1.98 |
| PC 36:5 | 779.5465 | 7.95 | −4 | 0.93 | −0.51 | 1.35 | −48 | 0.19 | 0.30 | 1.43 |
| PC O-18:0/20:4 | 795.6141 | 10.20 | −0.45 | 1.52 | −0.16 | 1.34 | ||||
| LysoPC O-18:1 | 507.3689 | 5.95 | −42 | 0.17 | −0.59 | 2.21 | 59 | 0.45 | 0.27 | 0.46 |
| LysoPC O-16:0 | 481.3532 | 5.80 | −34 | 0.50 | −0.64 | 2.81 | −22 | 0.61 | 0.34 | 1.30 |
| LysoPC 18:2 sn-2 | 519.3325 | 5.40 | 69 | 0.30 | 0.30 | 1.07 | −56 | 0.049 | 0.55 | 1.90 |
| LysoPC 18:3 | 517.3168 | 5.05 | 79 | 0.28 | 0.16 | 0.71 | −53 | 0.26 | 0.53 | 1.72 |
| LysoPC 22:4 | 571.3638 | 5.85 | 28 | 0.47 | 0.55 | 1.51 | −40 | 0.018 | 0.56 | 1.96 |
| LysoPC 20:4 | 543.3325 | 5.40 | 42 | 0.46 | 0.21 | 1.01 | −42 | 0.01 | 0.62 | 2.16 |
| LysoPC 20:4 sn-2 | 543.3325 | 5.35 | 49 | 0.07 | −0.50 | 1.43 | −27 | 0.11 | 0.45 | 1.76 |
| LysoPC 20:4 sn-1 | 543.3325 | 5.35 | 20 | 0.74 | −0.01 | 0.07 | −72 | 0.02 | 0.54 | 2.91 |
| LysoPC 22:6 | 567.3325 | 5.40 | 101 | 0.04 | 0.81 | 2.21 | −18 | 0.40 | 0.26 | 1.11 |
| LysoPE 22:6 sn-2 | 525.2855 | 5.35 | 80 | 0.23 | −0.54 | 2.35 | −45 | 0.29 | −0.34 | 1.26 |
| LysoPE 22:6 sn-1 | 525.2855 | 5.35 | 118 | 0.09 | −0.56 | 2.03 | −4 | 0.86 | −0.27 | 1.10 |
| Tetradecanedioic acid | 258.1831 | 4.35 | 21 | 0.44 | −0.20 | 0.78 | 51 | 0.005 | −0.53 | 2.01 |
| Linoleic acid | 280.2402 | 7.05 | 80 | 0.01 | −0.59 | 2.29 | −65 | 0.13 | −0.12 | 0.67 |
| HETE | 320.2351 | 5.70 | −66 | 0.10 | 0.64 | 2.56 | −4 | 0.93 | 0.38 | 1.69 |
| HETE | 320.2351 | 5.70 | −62 | 0.10 | 0.57 | 1.89 | −65 | 0.13 | 0.43 | 2.15 |
| HODE | 298.2508 | 5.85 | −33 | 0.09 | 0.51 | 1.43 | 20 | 0.43 | −0.26 | 1.06 |
| HDoHE | 344.2351 | 5.70 | −61 | 0.11 | 0.57 | 1.90 | −28 | 0.53 | 0.43 | 2.15 |
| C18:2 Sphingosine | 297.2668 | 5.85 | −37 | 0.25 | −0.41 | 1.60 | −48 | 0.01 | 0.65 | 2.78 |
| Leukotriene A4 | 318.2195 | 5.45 | −81 | 0.02 | 0.74 | 3.16 | −43 | 0.21 | 0.16 | 0.79 |
| Leukotriene A4 | 318.2195 | 5.45 | −71 | 0.01 | 0.64 | 2.58 | −15 | 0.71 | 0.24 | 1.14 |
| Leukotriene A4 | 318.2195 | 5.45 | −52 | 0.10 | 0.58 | 1.40 | −41 | 0.14 | 0.41 | 2.03 |
| Acetylcarnitine | 203.1158 | 0.25 | 55 | 0.06 | 0.54 | 2.00 | 92 | 0.002 | −0.60 | 2.88 |
| Linoleamide | 279.2562 | 5.30 | 6 | 0.93 | −0.01 | 0.05 | −45 | 0.09 | 0.53 | 1.51 |
| Dodecanamide | 199.1936 | 5.20 | −28 | 0.49 | −0.81 | 2.48 | −38 | 0.16 | 0.48 | 1.10 |
| Taurocholic acid | 515.2917 | 2.30 | −27 | 0.35 | −0.39 | 0.39 | −59 | 0.07 | 0.66 | 2.43 |
| Deoxycholic acid glycine conjugate | 449.3141 | 4.30 | 70 | 0.14 | 0.55 | 1.42 | 6 | 0.75 | −0.29 | 0.91 |
| Ornithine | 132.0899 | 0.25 | 4 | 0.83 | 0.12 | 0.05 | −45 | 0.047 | 0.53 | 1.83 |
VIP = variable importance in the projection, RT = retention time.