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. 2019 May 14;21(7):641–652. doi: 10.1016/j.neo.2019.04.007

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Cell Motility Altered in LDHA/PDHA1 Deficient HNSCC Cells. (A) Trans-well based cell migration and invasion was assayed in LDHA/PDHA1 deficient HNSCC cells. LDHA loss led to decreased (B) migration and (C) invasion where PDHA1 decrease results in the opposite effect in HNSCC cells. The changes of cell motility could result from (D) different extracellular lactate production; (E) rearrangement of lamellipodia-like (yellow lined and arrows) and filopodia-like (white arrows) F-actin derived structures; and (F) altered EMT-associated mRNA expression. (G) Microarray analysis showed a reverse correlation between LDHA and LDHB/PDHA1 mRNA expression in serial subcutaneous injected in situ (S1/2/3) and tail vein injected metastatic (M1/M5) SAS derived tumors. Data are presented as mean ± SEM (N≥3). ***P < .001; **P < .01; *P < .05.