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. 2019 Apr 5;8(4):316. doi: 10.3390/cells8040316

Figure 4.

Figure 4

Structure of the asymmetric crystallographic dimer of the EGFR kinase domain (taken, with permission, from Zhang et al. [36]). (a) Shows an overview of the dimer (PDB:2GS6) compared with the cyclin-dependent kinase-2 (CDK2)/cyclin A complex (PDB: 1HCL). (b) Shows detail of the dimer interface. The first zoomed-in area (left) shows a ribbon structure for Monomer B with its hydrophobic interface residues highlighted. The second zoomed-in area (right) shows the reverse, with the hydrophobic interface residues of monomer A highlighted.