Figure 1.

Schematic of prelamin A and lamin C proteins with the corresponding coding exons of the LMNA gene and the positions of the affected amino acids cited in this review. In red is the N terminus head, in bright pink are coils 1a, b and 2, in blue are linkers 1 and 2, in grey is the part of the C terminal tail common to both lamins A and C, in cyan is the part of the C terminal tail specific to lamin A and in bright green is the part of the C terminal tail specific to lamin C. fs means frameshift starting at the indicated amino acid. * and ** denote lamin-A- or lamin-C-specific amino acid substitution respectively.