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. 2019 Apr 4;11(4):167. doi: 10.3390/pharmaceutics11040167

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Multivariate analysis of the physicochemical properties of the four HQ formulations and their permeability across mouse skin and Strat-M^®. (a) Three-dimensional (3D) scatter plot comparing MV and Jss across mouse skin and Strat-M^®; (b) Correlation loading plot obtained after principal component analysis (PCA). The average value of the following parameters was included for the MVA analysis: mean size in volume (MV), viscosity, span, water content, stability at 25 °C and 40 °C at 30 days expressed as the percentage remaining of HQ, Jss across mouse skin and Strat-M^®.