Table 2.
Sample Characteristics—Baseline Brain and Cognition, and Change in Lobar Cortical Gray
| Brain/cognition category | Demented | MCI | Normal | Total |
|---|---|---|---|---|
| Prefrontal gray BLa—M (SD) | −3.3 (±8.7) | −0.6 (±8.1) | 1.2 (±8.1) | 0.0 (±8.3) |
| Prefrontal gray BLa—Missing | 8 (14.0%) | 21 (12.7%) | 20 (8.7%) | 49 (10.8%) |
| Temporal gray BLa—M (SD) | −9.6 (±10.5) | −2.0 (±9.2) | 3.7 (±7.1) | 0.1 (±9.4) |
| Temporal gray BLa—Missing | 8 (14.0%) | 21 (12.7%) | 20 (8.7%) | 49 (10.8%) |
| Parietal gray BLac—M (SD) | −2.8 (±5.1) | −0.7 (±5.7) | 1.2 (±4.9) | 0.0 (±5.4) |
| Parietal gray BLac—Missing | 8 (14.0%) | 21 (12.7%) | 20 (8.7%) | 49 (10.8%) |
| Occipital gray BLa—M (SD) | −1.1 (±5.3) | −0.8 (±6.5) | 0.9 (±4.8) | 0.0 (±5.6) |
| Occipital gray BLa—Missing | 8 (14.0%) | 21 (12.7%) | 20 (8.7%) | 49 (10.8%) |
| Hippocampus BLa—M (SD)) | −0.8 (±0.7) | −0.2 (±0.7) | 0.3 (±0.6) | 0.0 (±0.8) |
| Hippocampus BLa—Missing | 9 (15.8%) | 22 (13.3%) | 25 (10.8%) | 56 (12.3%) |
| White matter hyperintensity BL—M (SD) | 17.0 (±17.8) | 14.2 (±15.4) | 10.1 (±11.8) | 12.4 (±14.2) |
| White matter hyperintensity BL—Missing | 8 (14.0%) | 21 (12.7%) | 20 (8.7%) | 49 (10.8%) |
| Prefrontal gray changeb—M (SD) | −1.4 (±.7) | −1.2 (±0.9) | −0.8 (±0.5) | −1.0 (±0.7) |
| Temporal gray changeb—M (SD) | −1.9 (±1.0) | −1.3 (±1.0) | −0.7 (±0.5) | −1.0 (±0.8) |
| Parietal gray changebc—M (SD) | −1.4 (±1.1) | −1.1 (±0.8) | −0.7 (±0.5) | −0.9 (±0.7) |
| Occipital gray changeb—M (SD) | −0.5 (±.8) | −0.5 (±0.7) | −0.3 (±0.6) | −0.4 (±0.6) |
| Episodic memory BL—M (SD) | −1.0 (±.5) | −0.4 (±0.7) | 0.5 (±0.8) | −0.0 (±0.9) |
| Semantic memory BL—M (SD) | −0.8 (±1.0) | 0.0 (±0.8) | 0.2 (±0.9) | 0.0 (±0.9) |
| Executive function BL—M (SD) | −0.7 (±0.9) | −0.1 (±0.7) | 0.4 (±0.9) | 0.1 (±0.9) |
| Spatial BL—M (SD) | −0.6 (±1.0) | −0.1 (±0.9) | 0.2 (±0.9) | 0.0 (±1.0) |
Note. BL = baseline.
a
Residualiized for intracranial volume.
b
Log Jacobian × 100.
c
Minus postcentral gyrus.