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. 2019 May 14;6(2):ENEURO.0399-18.2019. doi: 10.1523/ENEURO.0399-18.2019

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Copyright © 2019 Govier-Cole et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — BMP4 signals via BMPR1 in OPCs to promote myelin formation in vitro. A, Representative micrographs of myelinating DRG/OPC cocultures treated with vehicle (control), BMP4, LDN-193189 (LDN), or both LDN-193189 and BMP4 (LDN+BMP4) for 14 d and immunostained for MBP and Neurofilament. Arrows indicate MBP⁺ myelin segments colabeled with NFL⁺ axons. B, Quantification of the number of MBP⁺ myelinated axonal segments per field from these cocultures. BMP4 treatment significantly reduced the number of MBP⁺ myelin segments compared with cocultures, which is blocked by the pretreatment of LDN-193189 (LDN+BMP4; N = 4 independent cocultures/group). *p < 0.05, ****p < 0.0001. Scale bar, 30 µm.