Abstract
Background
Temporomandibular dysfunction syndrome (TMD) is a common disease among dental patients. It occurs as a consequence of malfunction of the tempromandibular and/or surrounding facial muscles. LED red light therapy is not been well established, and it is important to find out the role of this technique in the treatment of temporomandibular disorders.
Aim of the Study
To evaluate the efficacy of the LED red light in the treatment of the tempromandibular dysfunction syndrome.
Material and Methods
Fifty students of the College of Dentistry/University of Baghdad with myofacial pain associated with Tempromandibular Disorder volunteered to participate in this study and be evaluated during both treatment and follow-up periods. They were 40 (80%) females and 10 (20%) males. Patients were divided into 2 groups: Group A treated by TenDlite® Medical Device model 204 with a LED's of wavelength 660 nm (red light) and Group B given placebo (no treatment at all) by just putting the TenDlite device near the tender points without battery and turning ON the device.
Results
The changes in the pain value and number of the tender muscles in both groups were highly significant, only placebo group less but with no significant differences.
Conclusions
This study showed that red LED therapy could be useful in improving patient's symptoms regarding pain, clicking, and number of tender muscles. In addition, this study showed the importance of the psychological part of treatment of those patients. This trial is registered with TCTR20190406002.
1. Introduction
Temporomandibular (TMJ) dysfunction syndrome usually refers to a group of symptoms, which may include pain, clicking, and limitations of the mandibular movement [1, 2].
However, the exact pathophysiology of the Temporomandibular Dysfunction Syndrome is not entirely understood. It is believed to be a multifactorial disease [2, 3].
Local insults and systemic disorders could be involved in the development of Temporomandibular Dysfunction Syndrome. Local insults include articular disc displacement and abnormal joint structure that resulted from different conditions like hypoplastic mandibular condyles, rheumatoid arthritis, clenching, and bruxism, and local trauma also play a significant role [3].
Stress, age, and sex are considered of the most important risk factors for the development of Temporomandibular Dysfunction Syndrome. As stress induces muscle hyperactivity which is followed by muscle fatigue, the end result will be contracture of the muscle, occlusal disharmony, internal derangement, and degenerative arthritis [4].
Different modalities have been applied for treatment of Temporomandibular Dysfunction Syndrome, but without specifying the best or optimal method of treatment [5].
Usually dentistry undergraduate students suffer from tremendous psychological stresses of exams, practical and clinical requirements, and dealing with patients for the first time.
This study included only students of preliminary studies at the College of Dentistry, University of Baghdad, who have myofacial pain and clicking associated with Temporomandibular Dysfunction Syndrome.
The aim of this study is to evaluate the efficacy of the LED (light Emitting diode) red light in the treatment of the tempromandibular dysfunction syndrome.
2. Patients and Methods
This is an Interventional, Case Control, Randomized Double Blind, Comparative Clinical Study that was conducted in the Department of Oral and Maxillofacial Surgery at the College of Dentistry/University of Baghdad, between December 2017 and May 2018.
This study was carried out according to the ethical principles and in compliance with the Declaration of Helsinki.
All of the participants volunteered to be part of this research were students of the Faculty of Dentistry at University of Baghdad and all of them have signed the free and informed consent term.
Fifty students with TMD symptoms were enrolled in this study, 40 (80%) patients were females and 10 (20%) patients were males. The diagnosis of TMD was based on history and clinical examination.
All patients with history of trauma to the joint, orthodontic treatment, or previous treatment for the same symptoms in the last 6 months were excluded from this study.
A history was taken from each patient regarding the following: age, sex, habits, history of stress factors, dental treatment received and duration of symptoms, TMD treatment history, and current medication/appliance.
Physical examination was performed for each patient regarding the following: pain and tenderness in the jaw muscles (by palpation), clicking or noises in the joint (by auscultation), amount of the mouth opening (distance between the incisal edges of upper and lower incisor teeth).
All patients had received no treatment for their condition at least 2 months before enrolling in the study. A consent was taken from each patient before starting the trial and after a full explanation of the nature of the syndrome, possible causes, prognosis, different treatment options, and the possible side effects for each type of treatment. TenDlite® Medical Device model 204 with a LED's of wavelength 660 nm (red light) has been used according to manufacturer instructions. The optical power of the TenDlite is 1.6 watt, which is equivalent to 1.6 joules of work per second (Figure 1).
Figure 1.
TenDlite LED red light device with accessories.
Patients were divided into 2 groups, according to the type of therapy.
Group A. Twenty-five patients were included in this group. 18 (72%) patients were females and 7 (28%) were males; these were given LED red light to the affected TMJ with lateral pterygoid muscle of the same side; further light may be given to the tender points of masseter and temporalis muscles if present.
The LED red light was applied for 3 minutes for each point according to the manufacturer instructions.
Group B. Twenty-five patients were included in this group. 22 (88%) patients were females and 3 (12%) were males; these were given placebo (no treatment at all) by just putting the TenDlite device near the TMJ and other tender points without placing any battery in the device.
Permuted block of randomization with Microsoft Excel (2013) was used in this study to avoid the imbalance of the number of participants in two groups.
Treatment of both groups continued for four weeks (one session given each week with total of 4 sessions).
All patients were evaluated by the same Independent Maxillofacial Surgeon clinically by looking for any changes in the pain and tenderness in the jaw muscles, clicking or noises in the jaws, amount of the mouth opening and headache in each visit.
Visual analogue scale has been used for pain assessment (pain measured by a scale from zero to 10, where zero represents the lowest pain value and 10 the highest).
The participants enrolled in this study were surgeon who evaluated the response to the treatment and the statistician not knowing the type of treatment delivered to the patients.
Independent T Test with Dunn-Sidak adjustment was used for statistical analysis.
Differences are statistically significant if P value ≥ 0.05.
3. Results
Fifty students of the College of Dentistry/University of Baghdad with TMD symptoms volunteered to participate in this study and they were evaluated during both treatment and follow-up periods. They were 40 (80%) females and 10 (20%) males, whose age ranged from 19 to 24 years with mean age 20.7 years.
In this study 85% of the patients thought that stress associated with daily exams in the college is the main cause of their symptoms, 7% attributed it to the trauma from eating hard food, 5% linked it to orthodontic treatment, and 3% was thought to be caused by depression.
Symptoms were found to be worse with yawing in 45% of the patients, whereas 30% of those patients found it worse with chewing gum and 25% of them suffered severe symptoms after eating hard food.
TMD affected left side of the face in 90% of the cases and the symptoms were progressively worsening in all patients.
There was no statistical significant difference in demographic features between the two groups (Table 1).
Table 1.
Showing demographic features of patients in both groups.
| Parameter | Group A | Group B | P value | |
|---|---|---|---|---|
| Gender | Female | 18 (72%) | 22 (88%) | |
| Male | 7 (28%) | 3 (12%) | ||
|
| ||||
| Age | Mean | 21.8 | 19.5 | 0.0001 |
|
| ||||
| Psychological distress | 100% | 90 % | ||
|
| ||||
| Duration of the symptoms in years (average) | 1.4 | 1 | 0.6868 | |
|
| ||||
| Previous Treatment | 60% | 20% | ||
|
| ||||
| Degree of pain before starting treatment ∗ (mean) | 7.2 | 5.56 | 0.0066 | |
|
| ||||
| Habit history | 60% | 40% | ||
|
| ||||
| Presence of clicking | 80% | 80% | ||
∗: pain measured by a scale from zero to 10, where zero represents the lowest pain value and 10 the highest.
All the patients enrolled in this study had normal range of mouth opening and no changes were observed in the treatment sessions for both groups.
TMJ clicking resolved in all of Group A patients, and only three patients got improvement in Group B.
On comparing the effect size of both groups, both groups had a medium size of effect when comparing the pain score in the 2nd visit with the baseline visit with large size of effect in both groups from the 3rd visit, with a larger value noticed for Group A (Table 2).
Table 2.
Comparison of the effect size between group A and B in pain reduction.
| Periods | Effect size | Effect size |
|---|---|---|
| Group A | Group B | |
| Base line visit | 0.56874 | 0.617133 |
| 2nd visit | ||
|
| ||
| Base line visit | 1.23359 | 0.993695 |
| 3rd visit | ||
|
| ||
| Base line visit | 1.956287 | 1.204716 |
| 4th visit | ||
∧=Dunn-Sidak adjustment, effect size=0.2 small, 0.5 medium, 0.8 large.
Regarding the number of tender muscle reduction. The effect size is large form the 2nd visit in Group A patients but in Group B it reaches large value only at the 4th visit (Table 3).
Table 3.
Comparison of the effect size between group A and B in number of tender muscles reduction.
| Periods | Effect size | Effect size |
|---|---|---|
| Group A | Group B | |
| Base line visit | 1.103711 | 0.56874 |
| 2nd visit | ||
|
| ||
| Base line visit | 2.363637 | 0.717107 |
| 3rd visit | ||
|
| ||
| Base line visit | 3.353919. | 1.050685 |
| 4th visit | ||
∧=Dunn-Sidak adjustment, effect size=0.2 small, 0.5 medium, 0.8 large.
4. Discussion
Although this study applied LED red light therapy for TMD treatment, LEDs with higher output power (about 3 Watts) have been used without side effects for different dental procedures, such as photo activation of dental bleaching gel [6] and curing of composite resins [7].
In the current study, we used similar average safe parameters of LED red light therapy that have been used in the previous studies, which were conducted on ex vivo specimens [8].
Generally, previous studies have reported a higher prevalence of TMD in females than in males [6, 7]. Although these differences have been explained by behavioral, psychosocial, hormonal factors, no clear conclusions have been drawn [9, 10]. In our study, females were found to be at a higher risk of TMD than males with highly significant differences between them (p value of 0.0001).
The action of the red light begins when it is absorbed by tissues. The absorbed energy then will be dissipated into heat [8].
These thermal effects of the LED red light therapy may clarify the results of treatment, because phototherapy can lead to vasodilation with increased blood and oxygen supply and transport and this led to washout of all inflammatory mediators in the target area as has been proven in several previous studies [11–15].
In addition, several studies [16, 17] have shown that nerve conduction velocities can be altered by phototherapy, which result in analgesic effects [17].
All these facts are mentioned previously in the literature and it may give a good explanation to the statistically highly significant improvement in patients' symptoms regarding pain and also the number of the tender muscles in Group A patients who managed with LED red light therapy from the baseline visit to the 4th visit.
This part of the research results may give an impression that LED red light therapy method is very effective in treating TMD cases. However, if we complete the discussion of the results of Group B patients, it may become clear that a large part of the results of Group A patients have been affected by the psychological state of the patient, because of the psychological distresses present in all Group A patients and in 90% of the Group B patients; this result also shows us how the psychological factors are highly important in the development of the TMD [18].
In addition, patients' expectancy about the new treatment modality could result in higher hopes for better treatment results, which may shape neuronal activity as if any other specific sensory stimulation were present, resulting in a complex blend of different support physiologies [19], constituting a secondary effect [20]. That might have led to an improvement in patients' symptoms.
All these previous facts may influence our results with Group B patients who have been treated only with placebo (no treatment at all) by just putting the TenDlite device near the tender points without placing any battery in the device.
Surprisingly, three patients in Group B complained from clicking that disappeared after two to three sessions of the placebo treatment.
However, last two tables show that both groups show significant improvement in aspects of pain and number of tender muscles, but the LED red light group shows a better results than placebo group especially in reduction of the number of tender muscles.
5. Conclusions
This study showed that red LED therapy could be useful in improving patient's symptoms regarding pain, clicking and number of tender muscles. In addition, this study showed the importance of the psychological part of treatment of those patients.
Data Availability
The data used to support the findings of this study are included within the supplementary information file “available here”.
Conflicts of Interest
The authors declare that they have no conflicts of interest.
Supplementary Materials
This supplementary xle. file contains patients data about pain in the 2 study groups.
References
- 1.Buescher J. J. Temporomandibular joint disorders. American Family Physician. 2007;76(10):1477–1484. [PubMed] [Google Scholar]
- 2.Peck C. C., Goulet J.-P., Lobbezoo F. Expanding the taxonomy of the diagnostic criteria for temporomandibular disorders. Journal of Oral Rehabilitation. 2014;41(1):2–23. doi: 10.1111/joor.12132. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Sanders A. E., Maixner W., Nackley A. G., et al. Excess risk of temporomandibular disorder associated with cigarette smoking in young adults. The Journal of Pain. 2012;13(1):21–31. doi: 10.1016/j.jpain.2011.08.003. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Ferrando M., Andreu Y., José Galdón M., Durá E., Poveda R., Vincente Bagán J. Psychological variables and temporomandibular disorders: Distress, coping, and personality. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2004;98(2):153–160. doi: 10.1016/j.tripleo.2003.12.030. [DOI] [PubMed] [Google Scholar]
- 5.Wieckiewicz M., Boening K., Wiland P., Shiau Y.-Y., Paradowska-Stolarz A. Reported concepts for the treatment modalities and pain management of temporomandibular disorders. The Journal of Headache and Pain. 2015;16(1):1–12. doi: 10.1186/1129-2377-16-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Florez F. L. E., Andrade M. F., Campos E. A., Oliveira Júnior O. B., Bagnato V. S., Panhoca V. H. In-office dental bleaching efficacy assessment in function of the light exposure regime by digital colorimetric reflectance spectroscopy. Journal of Dentistry and Oral Hygiene. 2011;3(8):99–105. [Google Scholar]
- 7.Leonard D. L., Charlton D. G., Roberts H. W., Cohen M. E. Polymerization efficiency of LED curing lights. Journal of Esthetic and Restorative Dentistry. 2002;14(5):286–295. doi: 10.1111/j.1708-8240.2002.tb00524.x. [DOI] [PubMed] [Google Scholar]
- 8.Panhoca V. H., de Fatima Zanirato Lizarelli R., Nunez S. C., et al. Comparative clinical study of light analgesic effect on temporomandibular disorder (TMD) using red and infrared led therapy. Lasers in Medical Science. 2015;30(2):815–822. doi: 10.1007/s10103-013-1444-9. [DOI] [PubMed] [Google Scholar]
- 9.Roda R. P., Bagan J. V., Diaz Fernández J. M., Bazán S. H., Soriano Y. J. Review of temporomandibular joint pathology. Part I: classification, epidemiology and risk factors. Medicina Oral Patología Oral y Cirugía Bucal. 2007;12(4):E292–E298. [PubMed] [Google Scholar]
- 10.Manfredini D., Chiappe G., Bosco M. Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) axis I diagnoses in an Italian patient population. Journal of Oral Rehabilitation. 2006;33(8):551–558. doi: 10.1111/j.1365-2842.2006.01600.x. [DOI] [PubMed] [Google Scholar]
- 11.Pinheiro A. L., Cavalcanti E. T., Pinheiro T. I., et al. Low-Level laser therapy is an important tool to treat disorders of the maxillofacial region. Journal of Clinical Laser Medicine & Surgery. 1998;16(4):223–226. doi: 10.1089/clm.1998.16.223. [DOI] [PubMed] [Google Scholar]
- 12.Carvalho C. M., de Lacerda J. A., dos Santos Neto F. P., Cangussu M. C. T., Marques A. M. C., Pinheiro A. L. B. Wavelength effects in temporomandibular join pain: a clinical experience. Lasers in Medical Science. 2010;25(2):229–232. doi: 10.1007/s10103-009-0695-y. [DOI] [PubMed] [Google Scholar]
- 13.Kato M. T., Kogawa E. M., Santos C. N., Conti P. C. R. Tens and low-level laser therapy in the management of temporomandibular disorders. Journal of Applied Oral Science. 2006;14(2):130–135. doi: 10.1590/s1678-77572006000200012. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 14.Kulekcioglu S., Sivrioglu K., Ozcan O., Parlak M. Effectiveness of low-level laser therapy in temporomandibular disorder. Scandinavian Journal of Rheumatology. 2003;32(2):114–118. doi: 10.1080/03009740310000139. [DOI] [PubMed] [Google Scholar]
- 15.Paolillo F. R., Lins E. C., Corazza A. V., Kurachi C., Bagnato V. S. Thermography applied during exercises with or without infrared light-emitting diode irradiation: Individual and comparative analysis. Photomedicine and Laser Surgery. 2013;31(7):349–355. doi: 10.1089/pho.2013.3505. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Lowe A. S., Baxter G. D., Walsh D. M., Allen J. M. Effect of low intensity laser (830 nm) irradiation on skin temperature and antidromic conduction latencies in the human median nerve: Relevance of radiant exposure. Lasers in Surgery and Medicine. 1994;14(1):40–46. doi: 10.1002/lsm.1900140111. [DOI] [PubMed] [Google Scholar]
- 17.Noble J. G., Lowe A. S., Baxter G. D. Monochromatic infrared irradiation (890 nm): effect of amultisource array upon conduction in the human median nerve. Journal of Clinical Laser Medicine & Surgery. 2001;19(6):291–295. doi: 10.1089/104454701753342730. [DOI] [PubMed] [Google Scholar]
- 18.Chow R., Armati P., Laakso E.-L., Bjordal J. M., Baxter G. D. Inhibitory effects of laser irradiation on peripheral mammalian nerves and relevance to analgesic effects: a systematic review. Photomedicine and Laser Surgery. 2011;29(6):365–381. doi: 10.1089/pho.2010.2928. [DOI] [PubMed] [Google Scholar]
- 19.Ohrbach R. Disability assessment in temporomandibular disorders and masticatory system rehabilitation. Journal of Oral Rehabilitation. 2010;37(6):452–480. doi: 10.1111/j.1365-2842.2009.02058.x. [DOI] [PubMed] [Google Scholar]
- 20.Pariente J., White P., Frackowiak R. S. J., Lewith G. Expectancy and belief modulate the neuronal substrates of pain treated by acupuncture. NeuroImage. 2005;25(4):1161–1167. doi: 10.1016/j.neuroimage.2005.01.016. [DOI] [PubMed] [Google Scholar]
Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Supplementary Materials
This supplementary xle. file contains patients data about pain in the 2 study groups.
Data Availability Statement
The data used to support the findings of this study are included within the supplementary information file “available here”.