Figure 5.

Absorbed dose and activity and absorbed dose rate distributions in tumor sections compared to histology and Ki-67 staining, 1 - 30 days after administration of ¹⁷⁷Lu-hu11B6. A. Mean and maximum absorbed dose rate as measured in tumor sections together with mean tumor absorbed dose from macrodosimetry calculated for the injected activity of the measured group. B. Absorbed dose rate ratio of Max to Mean. C. From left to right: Representative digital autoradiography images of activity uptake individually scaled to %IA/g. The same tissue sections stained with hematoxylin and eosin. Adjacent sections stained for the proliferation marker Ki-67. Finally, the distribution of absorbed dose rate at the moment of sacrifice, collectively scaled to mGy/h. From top to bottom 4, 9, 14 and 30 days after injection.