The future of Healthcare is personalized medicine. This means that prevention and treatment are specific to each person. It can’t be done so without a deep molecular profiling of both genes and proteins using high throughput laboratory techniques.
In this context we present “Analyzing Biomolecular Interactions by Mass Spectrometry”, edited by Jeroen Kool and Wilfried M.A. Niessen, a comprehensive textbook on a highly sensitive analytical method in biomolecular interactions field.
The book begins with a tutorial about Mass Spectrometry (MS). The authors present the principle of MS, different types of mass spectrometers and how acquisition data are interpreted.
The authors present the mass spectrometry techniques in a smart manner linking the old techniques with the new Mass spectrometry protocols.
Special attention is dedicated to sample preparation and data analysis, two important steps in MS assays. Another strength of the book is represented by the case studies on some important issues on biomolecular interaction such as protein-lipid interactions, drug binding to proteins, binding models of kinase inhibitors.
An important chapter is dedicated to Methodologies for Effect-Directed Analysis: Environmental Applications, Food Analysis and Drug Discovery. This is of special importance for endocrinologists both for new therapeutical strategies and prevention against endocrine disruptors.
Other chapters address to MS Binding Assays, Metabolic profiling approaches, Immunoreactivity, Immunoaffinity sample preatreatment in capillary electrophoresis – mass spectrometry assays.
Graphic and illustrative materials help at reading and understanding of the text. The principles and applications of mass spectrometry presented in the book represent a useful manual for doctoral students and researchers and, why not, a challenge for new exciting discoveries.