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. Author manuscript; available in PMC: 2020 Jul 15.
Published in final edited form as: Neuroimage. 2019 Apr 4;195:320–332. doi: 10.1016/j.neuroimage.2019.03.073

Figure 6. Results of longitudinal mediation analyses.

Figure 6.

A-D: Results of Preacher and Hayes mediation analyses with significant direct or indirect effects indicated by solid arrows with non-significant direct or indirect effects are shown by dashed arrows. Standardized β-coefficients are shown next to the corresponding path with significant effects shown in bold and non-significant effects in italics. For all models, the total effect of X on Y (c) is shown above the horizontal arrow, while the direct effect of X on Y (c’) after accounting for indirect effects is shown below the horizontal arrow. All models included the subset of participants used in longitudinal analyses (n = 29). A: Results indicated that the relationship between CSF Tau/Aβ42 ratio and average annual ΔEF was mediated by FA in DMN-naWM. B: Results indicated that the relationship between CSF Tau/Aβ42 ratio and average annual ΔEF was partially mediated by FA in ECN-naWM. C-D: Results indicated that CSF Tau/Aβ42 did not mediate the relationship between FA in DMN-naWM and average annual ΔEF (C) or the relationship between FA in ECN-naWM and ΔEF (D).