. 2018 Dec 4;6:11–20. doi: 10.1016/j.eclinm.2018.11.003

Table 3.

Antimicrobial susceptibility profiles of 43 clinical NDM-producing E. coli strains.

Drug class	Antimicrobial agents	MIC₅₀ μg/ml	MIC₉₀ μg/ml	Range μg/ml	%R	%I	%S
Aminoglycoside	Gentamicin	32	> 32	≤ 2–>32	69.8	2.3	27.9
Aminoglycoside	Amikacin	≤ 8	> 128	≤ 8–>128	23.3	0.0	76.7
β-lactams and β-lactamase Inhibitor	Piperacillin-tazobactam	256/4	> 256/4	≤ 8/4–>256/4	67.4	27.9	4.7
	Ampicillin-sulbactam	> 64/32	> 64/32	≤ 4/2–>64/32	97.7	0.0	2.3
	Ticarcillin-clavulanate	128/64	128/64	≤ 8/4–128/64	95.3	0.0	4.7
	Cefoperazone-sulbactam (2:1)	> 128/64	> 128/64	64/32–>128/64	100.0	0.0	0.0
Carbapenem	Imipenem	> 16	> 16	8–>16	100.0	0.0	0.0
Carbapenem	Meropenem	> 16	> 16	8–>16	100.0	0.0	0.0
Cephalosporin	Cefepime	> 32	> 32	2–>32	90.7	7.0	2.3
	Ceftazidime	> 32	> 32	32–>32	100.0	0.0	0.0
	Cefotaxime	> 32	> 32	32–>32	100.0	0.0	0.0
	Cefazolin	> 32	> 32	32–>32	100.0	0.0	0.0
	Cefuroxim	> 64	> 64	64–>64	100.0	0.0	0.0
Fluoroquinolone	Ciprofloxacin	8	> 8	≤ 0.25–>8	67.4	4.7	27.9
Fluoroquinolone	Levofloxacin	16	> 16	≤ 0.5–>16	58.1	7.0	34.9
Sulfonamide and Trimethoprim Antibiotic Combinations	Trimethoprim-sulfamethoxazole	8/152	8/152	≤ 1/19–8/152	95.3	0.0	4.7
Sulfonamide and Trimethoprim Antibiotic Combinations	Fosfomycin	16	> 512	≤ 4–>512	39.5	2.3	58.1
Tetracycline	Minocycline	8	16	≤ 2–16	46.5	20.9	32.6
Tetracycline	Tigecycline	0.5	2	≤ 0.25–4	2.3	9.3	88.4
Others	Aztreonam	4	64	≤ 2–64	41.9	4.7	53.5
	Chloramphenicol	32	32	≤ 8–32	74.4	2.3	23.3
	Colistin	≤ 1	4	≤ 1–>16	27.9	0.0	72.1
	Nitrofurantoin	≤ 32	64	≤ 32–128	9.3	7.0	83.7
	Piperacillin	> 256	> 256	≤ 8–>256	97.7	0.0	2.3

S, susceptible; I, intermediate resistant; R, resistant; MIC₉₀ and MIC₅₀ values were defined as the lowest concentration of the antibiotic at which 90% and 50% of the isolates were inhibited, respectively.