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. 2019 May 29;8(6):giz057. doi: 10.1093/gigascience/giz057

Table 1.

Parameter estimates (mobi-CTR model) for toxnodes specifically affected by diclofenac and naproxen in our experiment

Toxnode No.  Genes  Cluster  logFCmax  t max S max sum(CI) ratiol/t ratiom/t
Diclofenac Naproxen Diclofenac Naproxen Diclofenac Naproxen Diclofenac Naproxen Diclofenac Naproxen
1118 abcc2, CYP2C9, abcb5 "Taamira" 2.2 44.1 75.0 0.283 0.017 2.84 7.80 2.3 6.1 2.0 3.0
1179 cyp2k18 "Taamira" 4.8 48.9 69.0 0.283 0.017 12.02 34.12 2.3 6.1 2.0 3.0
2985 cbr1l, dhrs13l1, ethe1, mgst3b, sult6b1 "Pauline" 2.1 52.6 53.7 0.094 0.017 0.01 2.31 0.8 6.1 0.7 3.0
1062 lepa, pth1a "Deisy" 3.6 46.1 72.0 0.229 0.017 5.38 8.60 1.9 6.1 1.6 3.0
1241 hsp70l, hsp70.1, hsp70.2 "Deisy" 3.3 61.6 64.0 0.149 0.017 2.35 10.39 1.2 6.1 1.1 3.0
3039 dusp1, cyr61, gadd45ba, sik1, nfkbiaa "Karan" 1.7 55.2 72.9 0.146 0.005 0.07 0.11 1.2 1.8 1.0 0.9
3040 btg2, zgc:162730, tcima, ier2b, egr2a, jdp2b "Karan" 2.1 55.6 75.0 0.148 0.007 0.09 1.33 1.2 2.5 1.1 1.2
3100 socs3a, fosab "Karan" 3.3 53.8 73.0 0.180 0.006 2.59 2.96 1.5 2.1 1.3 1.1
3101 serpine1, atf3, junba "Karan" 3.2 54.0 75.0 0.137 0.007 0.53 7.96 1.1 2.5 1.0 1.2
1000 isg15 "Farajallah" 5.1 72.4 75.0 0.113 0.008 0.08 17.17 0.9 2.9 0.8 1.4
3161 socs3b, timp2b, CR855311.1, clu "Farajallah" 2.6 63.9 74.7 0.141 0.007 0.06 4.89 1.1 2.5 1.0 1.2
17 RF00020 "Tashina" 2.5 75.0 62.6 0.140 0.007 0.72 5.47 1.1 2.5 1.0 1.2
2041 si:ch211-125e6.5, si:ch211-125e6.14, zgc:172053 "Vincent" 1.5 75.0 74.3 0.164 0.004 0.02 0.61 1.3 1.4 1.2 0.7
3157 igfbp1b "Daniel" 2.7 73.6 75.0 0.136 0.009 0.08 5.83 1.1 3.2 1.0 1.6
3173 pdzd3a "Talon" Inline graphic2.0 49.3 74.0 0.131 0.007 Inline graphic0.05 Inline graphic4.33 1.1 2.5 0.9 1.2

ratiol/t: min(LC50)/min(EC50)toxnode; ratiom/t: min(EC50)morphological/min(EC50)toxnode. Positive sum(CI) indicates up-regulation, while negative indicates down-regulation of respective toxnodes. logFCmax represents maximum logFC per node across all treatments in our experiments.