Table 4.
Preliminary anti-microbial activity for compounds 13, 14, 17a,b and 19a.
| Microorganism | 13 | 14 | 17a | 17b | 19a | ST. (30 µg/mL) |
|---|---|---|---|---|---|---|
| Fungi | Amphotericin B | |||||
| Aspergillus niger | 21.2 ± 1.20 | 25.4 ± 1.20 | 24.3 ± 1.20 | 23.1 ± 1.20 | 25.0 ± 0.72 | 23.3 ± 0.58 |
| Geotricum candidum | 19.3 ± 0.85 | 20.9 ± 0.72 | 24.2 ± 1.20 | 23.6 ± 1.20 | 23.6 ± 0.63 | 25.2 ± 0.72 |
| G (+)Bacteria | Ampicillin | |||||
| Staphylococcus aureus | 16.8 ± 0.63 | 24.3 ± 0.63 | 23.6 ± 0.63 | 22.4 ± 0.63 | 23.8 ± 0.72 | 23.7 ± 0.63 |
| Staphylococcus epidermidis | 15.2 ± 0.58 | 22.8 ± 0.58 | 22.4 ± 0.72 | 20.9 ± 0.72 | 21.9 ± 0.72 | 22.4 ± 0.3 |
| Bacillis subtilis | 20.6 ± 0.58 | 21.6 ± 0.53 | 27.2 ± 0.63 | 29.8 ± 0.63 | 25.2 ± 0.63 | 32.4 ± 1.20 |
| Streptococcus pyogenes | NA | NA | NA | NA | NA | 24.5 ± 0.63 |
| G (−)Bacteria | Gentamicin | |||||
| Pseudomonas aeruginosa | NA | NA | NA | NA | NA | 22.3 ± 0.58 |
| Escherichia coli | 19.8 ± 1.20 | 24.3 ± 1.20 | 26.7 ± 1.20 | 24.3 ± 1.20 | 26.9 ± 1.20 | 25.4 ± 1.20 |
| Klebsiella pneumoniae | 18.3 ± 0.53 | 22.2 ± 0.44 | 25.3 ± 1.20 | 22.2 ± 1.20 | 26.3 ± 1.20 | 22.6 ± 0.63 |
| Salmonella typhimurium | 20.1 ± 0.63 | 21.1 ± 0.72 | 26.3 ± 0.58 | 24.8 ± 0.58 | 22.2 ± 0.58 | 23.3 ± 0.58 |
The tested compound has activity exceed the reference drug.
The tested compound has activity similar to reference drug.