Fig. 3.

a Increasing complexity of shared, single-database design when adding and closing comparisons in STAMPEDE. b Shared and unique database designs when adding and closing comparisons in FOCUS4. a and b key: ¹Arm G (abiraterone comparison) incorporated in 2011. ²Arms H–K sequentially incorporated over time; arms B–F closed. ³Current comparisons incorporated as per Fig. 1 (split into eight copies as seen in Fig. 4a). ⁴Initial release in 2014 with two databases, registration period and main trial period. Comparisons N and D are within the same database design. ⁵FOCUS4-B added within the existing database design and database. ⁶FOCUS4-C added within the same database with a new database design. FOCUS4-D and -B closed to recruitment. FOCUS4-N continues recruitment