In the Original Investigation entitled “A Randomized Trial of a Multicomponent Intervention to Promote Medication Adherence: The Teen Adherence in Kidney Transplant Effectiveness of Intervention Trial (TAKE-IT)” that appeared in the July 2018 issue of AJKD (Foster et al, volume 72, issue 1, pages 30–41), there was an error in the timing adherence analyses. This error was uncovered in the course of secondary analyses of the TAKE-IT data performed by the authors. In particular, the “Outcomes Measures” subsection of Methods on page 32, states that “timing adherence” was calculated as the “proportion of prescribed doses taken within 1 hour before to 2 hours after the prescribed dosing time.” In fact, the results presented in the article were calculated using timing adherence defined as doses taken within 3 hours before or after the prescribed dosing time. Thus, the first sentence of “Outcomes Measures” in column 2 of page 32 should read “Primary outcomes were daily ‘taking adherence’ (proportion of prescribed doses taken) and ‘timing adherence’ (proportion of prescribed doses taken within 3 hours before or after the prescribed dosing time), as measured using electronic monitoring.”
When the authors discovered this error, they repeated the analyses using the definition of timing adherence originally stated in the article. In this re-analysis, intervention participants had 100% timing adherence on 60% of days during the intervention interval, and had significantly greater odds of higher timing adherence scores (OR, 1.62; 95% CI, 1.14–2.29; P = 0.007) than controls, who had 100% timing adherence on 48% of days. These results are consistent with those reported in the article for the other definition of timing adherence, namely, that intervention participants had 100% timing adherence on 73% of days during the intervention interval and had significantly greater odds of higher timing adherence scores (OR, 1.74; 95% CI, 1.21–2.50; P = 0.003) than controls, who had 100% timing adherence on 61% of days. Thus, the authors conclude that the inferences in the paper demonstrating improved adherence in the intervention group are robust using either definition of timing adherence.