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. Author manuscript; available in PMC: 2019 Jul 23.
Published in final edited form as: Nature. 2019 Jan 23;566(7745):543–547. doi: 10.1038/s41586-019-0903-2

Extended Figure7. Clustering of snRNA-seq dataset by different origins.

Extended Figure7

a, tSNEs representing human Ctr and MS WM nuclei after dimensionality reduction with principal component analysis (PCA) at different resolutions. b-d, Clustering of snRNA-seq datasets by sample after dimensionality reduction with PCA (left) and canonical component analysis (CCA, right), highlighting Ctr/MS individual and lesion type combined (b), Ctr/MS individual (c) and lesion type (d) separately. e, Frequency distributions of OL sub-clusters by Ctr (left) and MS (right) individuals. (n=17799 cells derived from 5 Ctr and 4 MS patients).