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. 2019 Jan 24;104(6):1189–1201. doi: 10.3324/haematol.2018.202044

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Figure 5. — Co-expression of MA4 and A4M significantly enhances the emergence of both endothelial and hemogenic hemato-endothelial precursors. (A) Representative flow cytometry analysis of hemato-endothelial precursors (HEP) with hemogenic (CD45-CD31⁺CD43⁺CD34^dim/+) and endothelial (CD45⁻CD31⁺CD43⁻CD34⁺⁺) potential. (B,C) A4M co-operates with MA4 to boost the emergence of both endothelial (B) and hemogenic (C) HEP. Data are presented as the mean ± standard error of mean from three independent experiments. (D) Expression of RUNX1c and Ve-Cad in hemogenic and endothelial HEP. *P<0.05. EB: erythroid body; EV: empty vector.