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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Hepatology. 2019 Mar 10;70(2):666–681. doi: 10.1002/hep.30405

Fig. 1.

Fig. 1.

Decreased HNF4α protein expression and transcriptional activity during initiation of regeneration after partial hepatectomy. Western blot analysis of HNF4α adult isoform in (A) nuclear and (B) cytoplasmic lysates from mouse liver over a time course of 0 – 14 days after 2/3 PH. (C) Densitometric analysis of nuclear HNF4α blot. (D) qPCR analysis of HNF4α adult isoform mRNA over a time course of 0 – 14 days after 2/3 PH. Fold change calculated by comparison to 0 hr time point. qPCR analysis of positively regulated (E) and negatively regulated (F) HNF4α target genes at 0, 6 and 12 hr post-PH. Fold change calculated by comparison to 0 hr time point. *indicate significant difference at P ≤ 0.05.