Table 1:
Predicted Activity of Transcription Factors in HNF4α-KO Mice Compared to WT Mice 2 Days Post-PH.
| Day 2 Post-PH | |||
|---|---|---|---|
| Activated Pathways | Activation z-score | Inhibited Pathways | Activation z-score |
| JUN | 3.31 | HNF4A | −6.498 |
| EGR1 | 2.814 | HNF1A | −4.428 |
| RB1 | 2.497 | Esrra | −3.357 |
| IRF3 | 2.42 | PPARGC1A | −3.228 |
| FOXO4 | 2.377 | NFIX | −2.433 |
| EP300 | 2.305 | ZBTB20 | −2.294 |
| SPI1 | 2.248 | MED1 | −2.272 |
| THRAP3 | 2.219 | CLOCK | −2.219 |
| IRF6 | 2.215 | NFIC | −2.2 |
| SMAD4 | 2.201 | GATA2 | −2.059 |
| MTA1 | 2.194 | NKX2–3 | −2.04 |
| Gm21596/Hmgb1 | 2.169 | E2F1 | −2.027 |
| IRF7 | 2.163 | SMAD7 | −2.027 |
| SMAD2 | 2.068 | TAF4 | −2.008 |
| TCF3 | 2.022 | ||