Abstract
We describe the case of a 75 years old patient with a history of hepatocellular carcinoma, with acute respiratory failure due to tracheal obstruction by metastasis, successfully treated with airway disobstruction with rigid bronchoscope.
Case report
A 75 years old man, smoker, with a past history of a hepatic transplantation 13 years earlier for a hepatocellular carcinoma, was admitted to hospital with hemoptysis and dyspnea. He performed a chest CT scan, showing a solid lesion in the apical segment of right lower lobe with multiple confluent mediastinal adenopathies and right paratracheal lymphadenopathy (Fig. 1).
Fig. 1.
Chest enhanced computed tomography (CT) showed a solid lesion in the apical segment of right lower lobe with multiple confluent mediastinal adenopathies and right paratracheal lymphadenopathy
We practiced a videobronchoscopy that showed two small sessile lesions approximately 4.5 cm far from the carina on the right lateral wall of the trachea, which were removed with biopsy forceps. EBUS-TBNA was performed on the right paratracheal lymph node. The pathological findings were suggestive for hepatocarcinoma metastases and the patient was underwent chemotherapy.
After six months, the patient returned to the emergency room for wheezing and acute respiratory failure. Chest x-ray and CT scan showed deterioration of the radiological picture with stenosis of the tracheal lumen (Fig. 2).
Fig. 2.
Chest radiography and Computed Tomography (CT) showed a solid neoplastic lesion in the apical segment of the right lower lobe and significant stenosis of the tracheal lumen
The patient made videobronchoscopy that showed a vegetative neoformation which obstructed the tracheal lumen about 6.5 cm far from the true vocal cords (Fig. 3). The patient was intubated with a rigid bronchoscope Storz n°14 and we used laser photocoagulation to devascularize the lesion that was subsequently removed with a debulking maneuver, recanalizing the trachea (Fig. 4). The anatomopathological findings confirmed the previous diagnosis of hepatocarcinoma metastases (Fig. 5).
Fig. 3.
Bronchoscopy revealed that the tumor completely obstructed the tracheal lumen
Fig. 4.
After bronchial disobstruction, bronchoscopy revealed the recanalization of tracheal lumen
Fig. 5.
a) 100 enlargements, hematoxylin and eosin. Solid-growth non-small cell epithelial neoplasia. On the right fragment of ciliated cylindrical epithelium of the respiratory tract; b) 200 enlargements, same field; c) 200 enlargements, immunohistochemical anti-hepatocyte antigen: diffuse cytoplasmic granular positivity according to the hepatic origin of the neoplasia (hepatocellular carcinoma)
Discussion and Conclusion
The interest of this case is essentially due to two reasons: the rarity of the metastatic localization of hepatocellular carcinoma, which, as reported in the literature, has an incidence of 0.04% [1] and the importance of rigid bronchoscopy in the resolution of respiratory failure secondary to tracheal obstruction.
The lungs represent the most common site of liver metastases, reported in the 37–70% of cases at autopsy but less often clinically detected. These appear as nodules, often multiple and pleural effusion is common. Many nodules have the tendence to appear in the right-lower lobe, and the greatest degree of effusion occurs in the lower lobes, suggesting a probable transdiaphramatic spread. Occasionally, these metastases spread and give a miliary pattern [2]. Another possible mechanism is lymphatic spread, as probably happened to our patient. In fact mediastinal lymph nodes were involved since the tracheal lesion appeared.
Tracheal localization appears particularly important for the risk of incurring acute respiratory failure, as happened to our patient. Rigid bronchoscopic therapy is required for the treatment of patients with central airway obstruction. Various bronchoscopic techniques are available for tracheobronchial tumors, including neodymium-yttrium-aluminum-garnet (Nd-YAG) laser therapy, electrocautery, brachytherapy, photodynamic therapy, cryotherapy, and APC [3].
In conclusion, interventional bronchoscopy in most cases of acute airway obstruction from cancer is palliation, not cure. Reestablishment of patient airways may avoid hospitalization in a critical care unit, prolonged intubation and mechanical ventilation, and enhances patient’s ability to accept and undergo systemic chemotherapy, immunotherapy or radiation therapy [4]. It also determines an immediate symptomatic relief and an improvement in the quality of life [5, 6].
Acknowledgements
None.
Funding
The authors state that the case report was produced in the absence of economic founding sources.
Registration of research studies
Not applicable.
Guarantors
Giacomo Ghinassi, MD; Pasquale Imitazione, MD.
Provenance and peer review
Not commissioned, externally peer-reviewed.
Abbreviations
- APC
Argon Plasma Coagulation
- CT
Computed Tomography
- EBUS-TBNA
Endobronchial Ultrasound Transbronchial Needle Aspiration
Authors’ contributions
GG and PI conceptualized the study, performed a literature review and drafted the manuscript. AP and LBGM performed a literature review and drafted the manuscript. PM and RG performed a literature review and collected data. DA critically revised the article. All authors read and the final manuscript.
Ethics approval and consent to participate
No ethical committee approval was required for this case report by the Department of Clinical Medicine and Surgery, Section of Respiratory Diseases, Università Federico II, Monaldi hospital, Naples.
Consent for publication
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by Editor-in-Chief of this journal on request.
Competing interests
There is no conflict of interest for any of the authors.
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Contributor Information
Giacomo Ghinassi, Email: giacomo.ghinassi87@gmail.com.
Pasquale Imitazione, Email: pasquale.imitazione@gmail.com.
References
- 1.Madariaga Maria Lucia, Gaissert Henning A. Secondary tracheal tumors: a systematic review. Annals of Cardiothoracic Surgery. 2018;7(2):183–196. doi: 10.21037/acs.2018.02.01. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Dail DH, Hammer SP. Pulmonary Pathology Second Edition. Springer-Verlag. 1993;(35):1581–602.
- 3.Hayasaka Kazuki, Shiono Satoshi, Yanagawa Naoki. Multiple Endotracheal Metastases of Lung Cancer after Bronchoscopic Intervention. Internal Medicine. 2018;57(6):845–847. doi: 10.2169/internalmedicine.9542-17. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Functional Evaluation before and after Interventional Bronchoscopy. Henri G. Colt, Bollinger CT, Mathur PN (eds): Interventional Bronchoscopy. Prog Respir Res Basel, Karger. 2000;30:55–64.
- 5.Petrou M, Goldstraw P. The management of tracheobronchial obstruction: a review of endoscopic techniques. Eur J Cardiothorac Surg. 1994;8(8):436–441. doi: 10.1016/1010-7940(94)90086-8. [DOI] [PubMed] [Google Scholar]
- 6.Pierce R. J., Mestitz H., Simpson L. W., Daniel F. J. Endobronchial resection with the Nd-YAG laser - Two years experience in an Australian unit. Australian and New Zealand Journal of Medicine. 1990;20(2):120–126. doi: 10.1111/j.1445-5994.1990.tb01288.x. [DOI] [PubMed] [Google Scholar]