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. 2019 Jun 3;7:e7023. doi: 10.7717/peerj.7023

Figure 4. Histopathological examination of hind ankle joints of mice.

Figure 4

(A) Joint destruction is observed in the CIA mice. (B) UC treatment reduced synovitis, pannus, erosion, and inflammatory cells infiltration to the greatest degree. (C) BMSC treatment reduced synovitis, pannus, erosion, and inflammatory cells infiltration to some extent. (D) SHED had the least treatment effect on reducing synovitis, pannus, erosion, and inflammatory cells infiltration. (E) The histological score of each group was evaluated and presented in column. Scale bar, 75 μm. The data indicate the mean ± SD of six mice per group from three independent experiments. The data were analyzed using one-way ANOVA for comparison among multiple groups and Tukey’s multiple comparisons test for comparison between two groups (*P < 0.05, **P < 0.01).