Cristina Cifaldi
Cristina Cifaldi
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
1,†,
Immacolata Brigida
Immacolata Brigida
2San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy
2,†,
Federica Barzaghi
Federica Barzaghi
2San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy
3Pediatric Immunohematology and Bone Marrow Transplantation Unit, Scientific Institute for Research and Healthcare (IRCCS) San Raffaele Scientific Institute, Milan, Italy
4Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
2,3,4,†,
Matteo Zoccolillo
Matteo Zoccolillo
2San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy
4Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
2,4,
Valentina Ferradini
Valentina Ferradini
5Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
5,
Davide Petricone
Davide Petricone
4Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
4,
Maria Pia Cicalese
Maria Pia Cicalese
2San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy
3Pediatric Immunohematology and Bone Marrow Transplantation Unit, Scientific Institute for Research and Healthcare (IRCCS) San Raffaele Scientific Institute, Milan, Italy
6Vita Salute San Raffaele University, Milan, Italy
2,3,6,
Dejan Lazarevic
Dejan Lazarevic
7Center for Translational Genomics and BioInformatics, San Raffaele Scientific Institute, Milan, Italy
7,
Davide Cittaro
Davide Cittaro
7Center for Translational Genomics and BioInformatics, San Raffaele Scientific Institute, Milan, Italy
7,
Maryam Omrani
Maryam Omrani
2San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy
2,
Enrico Attardi
Enrico Attardi
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
1,
Francesca Conti
Francesca Conti
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
1,
Alessia Scarselli
Alessia Scarselli
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
1,
Maria Chiriaco
Maria Chiriaco
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
1,
Silvia Di Cesare
Silvia Di Cesare
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
1,
Francesco Licciardi
Francesco Licciardi
8Division of Immunology and Rheumatology, Department of Paediatric Infectious Diseases, Regina Margherita Children's Hospital, University of Turin, Turin, Italy
8,
Montin Davide
Montin Davide
8Division of Immunology and Rheumatology, Department of Paediatric Infectious Diseases, Regina Margherita Children's Hospital, University of Turin, Turin, Italy
8,
Francesca Ferrua
Francesca Ferrua
2San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy
3Pediatric Immunohematology and Bone Marrow Transplantation Unit, Scientific Institute for Research and Healthcare (IRCCS) San Raffaele Scientific Institute, Milan, Italy
6Vita Salute San Raffaele University, Milan, Italy
2,3,6,
Clementina Canessa
Clementina Canessa
9Pediatric Immunology, Department of Health Sciences, University of Florence, Florence, Italy
10Meyer Children's Hospital, Florence, Italy
9,10,
Claudio Pignata
Claudio Pignata
11Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy
11,
Silvia Giliani
Silvia Giliani
12Department of Molecular and Translational Medicine, A. Nocivelli Institute for Molecular Medicine, University of Brescia, Brescia, Italy
12,
Simona Ferrari
Simona Ferrari
13Unit of Medical Genetics, St. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy
13,
Georgia Fousteri
Georgia Fousteri
14Division of Immunology Transplantation and Infectious Diseases (DITID), Diabetes Research Institute (DRI) IRCCS San Raffaele Scientific Institute, Milan, Italy
14,
Graziano Barera
Graziano Barera
15Pediatric Department, San Raffaele Scientific Institute, Milan, Italy
15,
Pietro Merli
Pietro Merli
16Department of Onco-Hematology and Cell and Gene Therapy, Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
16,
Paolo Palma
Paolo Palma
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
1,
Simone Cesaro
Simone Cesaro
17Paediatric Hematology-Oncology, “Ospedale della Donna e del Bambino”, Verona, Italy
17,
Marco Gattorno
Marco Gattorno
18Center for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Giannina Gaslini, Genoa, Italy
18,
Antonio Trizzino
Antonio Trizzino
19Department of Pediatric Hematology and Oncology, “ARNAS Civico Di Cristina Benfratelli” Hospital, Palermo, Italy
19,
Viviana Moschese
Viviana Moschese
4Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
20Pediatric Immunopathology and Allergology Unit, University of Rome Tor Vergata Policlinico Tor Vergata, Rome, Italy
4,20,
Loredana Chini
Loredana Chini
4Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
20Pediatric Immunopathology and Allergology Unit, University of Rome Tor Vergata Policlinico Tor Vergata, Rome, Italy
4,20,
Anna Villa
Anna Villa
21Milan Unit, National Research Council (CNR) Institute for Genetic and Biomedical Research (IRGB), Milan, Italy
22Humanitas Clinical and Research Institute, Rozzano, Italy
21,22,
Chiara Azzari
Chiara Azzari
9Pediatric Immunology, Department of Health Sciences, University of Florence, Florence, Italy
10Meyer Children's Hospital, Florence, Italy
9,10,
Andrea Finocchi
Andrea Finocchi
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
4Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
1,4,
Franco Locatelli
Franco Locatelli
23Department of Pediatric Hematology and Oncology, Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, University of Rome La Sapienza, Rome, Italy
23,
Paolo Rossi
Paolo Rossi
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
4Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
1,4,
Federica Sangiuolo
Federica Sangiuolo
5Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
5,
Alessandro Aiuti
Alessandro Aiuti
2San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy
3Pediatric Immunohematology and Bone Marrow Transplantation Unit, Scientific Institute for Research and Healthcare (IRCCS) San Raffaele Scientific Institute, Milan, Italy
6Vita Salute San Raffaele University, Milan, Italy
2,3,6,*,‡,
Caterina Cancrini
Caterina Cancrini
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
4Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
1,4,*,‡,
Gigliola Di Matteo
Gigliola Di Matteo
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
4Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
1,4,‡
1Unit of Immune and Infectious Diseases, University Department of Pediatrics (DPUO), Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
2San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy
3Pediatric Immunohematology and Bone Marrow Transplantation Unit, Scientific Institute for Research and Healthcare (IRCCS) San Raffaele Scientific Institute, Milan, Italy
4Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
5Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
6Vita Salute San Raffaele University, Milan, Italy
7Center for Translational Genomics and BioInformatics, San Raffaele Scientific Institute, Milan, Italy
8Division of Immunology and Rheumatology, Department of Paediatric Infectious Diseases, Regina Margherita Children's Hospital, University of Turin, Turin, Italy
9Pediatric Immunology, Department of Health Sciences, University of Florence, Florence, Italy
10Meyer Children's Hospital, Florence, Italy
11Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy
12Department of Molecular and Translational Medicine, A. Nocivelli Institute for Molecular Medicine, University of Brescia, Brescia, Italy
13Unit of Medical Genetics, St. Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy
14Division of Immunology Transplantation and Infectious Diseases (DITID), Diabetes Research Institute (DRI) IRCCS San Raffaele Scientific Institute, Milan, Italy
15Pediatric Department, San Raffaele Scientific Institute, Milan, Italy
16Department of Onco-Hematology and Cell and Gene Therapy, Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, Rome, Italy
17Paediatric Hematology-Oncology, “Ospedale della Donna e del Bambino”, Verona, Italy
18Center for Autoinflammatory Diseases and Immunodeficiencies, IRCCS Giannina Gaslini, Genoa, Italy
19Department of Pediatric Hematology and Oncology, “ARNAS Civico Di Cristina Benfratelli” Hospital, Palermo, Italy
20Pediatric Immunopathology and Allergology Unit, University of Rome Tor Vergata Policlinico Tor Vergata, Rome, Italy
21Milan Unit, National Research Council (CNR) Institute for Genetic and Biomedical Research (IRGB), Milan, Italy
22Humanitas Clinical and Research Institute, Rozzano, Italy
23Department of Pediatric Hematology and Oncology, Scientific Institute for Research and Healthcare (IRCCS) Childrens' Hospital Bambino Gesù, University of Rome La Sapienza, Rome, Italy
Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland
✉*Correspondence: Alessandro Aiuti aiuti.alessandro@hsr.it
*Caterina Cancrini cancrini@med.uniroma2.it
This article was submitted to Primary Immunodeficiencies, a section of the journal Frontiers in Immunology
†These authors have contributed equally to this work
‡These authors shared last authorship
Received 2019 May 8; Accepted 2019 May 9; Collection date 2019.
Keywords: primary immunodeficiencies, Next Generation Sequencing, gene panels, Ion Torrent, Haloplex
Copyright © 2019 Cifaldi, Brigida, Barzaghi, Zoccolillo, Ferradini, Petricone, Cicalese, Lazarevic, Cittaro, Omrani, Attardi, Conti, Scarselli, Chiriaco, Di Cesare, Licciardi, Davide, Ferrua, Canessa, Pignata, Giliani, Ferrari, Fousteri, Barera, Merli, Palma, Cesaro, Gattorno, Trizzino, Moschese, Chini, Villa, Azzari, Finocchi, Locatelli, Rossi, Sangiuolo, Aiuti, Cancrini and Di Matteo.
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