Table 3.
Associations between number of protective genotypes (NPGs) and risk of pancreatic cancera
| NPGb | PanScan + PanC4 | OR (95% CI)c | P c | |
|---|---|---|---|---|
| Case (%) | Control (%) | |||
| 0 | 5137 (61.8) | 3900 (57.3) | 1.00 | |
| 1 | 2827 (34.0) | 2505 (36.8) | 0.86 (0.80–0.92) | <0.001 |
| 2 | 342 (4.1) | 397 (5.8) | 0.66 (0.56–0.76) | <0.001 |
| 3 | 7 (0.1) | 8 (0.1) | 0.78 (0.28–2.16) | 0.634 |
| Trend test | <0.001 | |||
| 0 | 5137 (61.8) | 3900 (57.3) | 1.00 | |
| 1–3 | 3176 (38.2) | 2910 (42.7) | 0.83 (0.78–0.88) | <0.001 |
NPG, number of protective genotypes.
aThe logistic regression analysis was performed in the combined data set of PanScan and PanC4 studies.
bProtective genotypes were rs3818626 TT, rs79447092 TA+AA and rs9895829 AG+GG.
cLogistic regression analyses with adjustment for age, sex and data source.