Fig. 4.

PCV composition of dominant Global Pneumococcal Sequence Clusters (GPSCs).

(A) Venn diagram of the number of dominant-GPSCs (n = 35) in which combinations of PCV7 VTs, PCV10/13 unique VTs and NVTs were observed in the same GPSC pre-PCV. Over one-third (15/35) of the dominant-GPSCs expressed both PCV7 (blue), PCV13-unique (purple) and NVT (orange) pre-PCV, shown in the overlap. Whilst 24/35 dominant-GPSCs had at least one isolate expressing an NVT pre-PCV (orange area). (B) PCV13 VT contribution to GPSCs pre-PCV. Each point represents a dominant-GPSC (n = 35) and the percentage of its pre-PCV isolates expressing PCV13-VTs, with boxplot of minimum, first quartile, median, third quartile, and maximum values. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)