Figure 3.

MODY1-Mediated HNF4A Haploinsufficiency in Early Foregut Development Affects Subsequent Hepatic and Pancreatic Development Signatures

(A and B) (A) qPCR analyses showing pattern of hepatic gene expression over a 24-day differentiation in control-hiPSC-derived hepatic cells and (B) comparison of hepatic gene expression changes between control and MODY1 hepatic cells.

(C and D) (C) qPCR analyses showing pattern of pancreatic β cell gene expression over a 35-day differentiation in control-hPSC-derived pancreatic β-like cells and (D) comparison of β cell gene expression changes between control and MODY1 pancreatic β-like cells.

Data are represented as mean ± SD of n = 3, representative of three independent experiments. *p < 0.05 versus control samples by Student's t test. See also Figure S4.