Table 1.
TRIMs’ roles in cancer. TRIM family members that control cell cycle progression have different role in controlling cancer development and progression.
| TRIM | Type of Cancer | Role | Reference |
|---|---|---|---|
| TRIM2 | ccRCC | tumor suppressor | [86] |
| TRIM3 | CC | tumor suppressor | [87] |
| HCC | tumor suppressor | [88] | |
| TRIM8 | GM | tumor suppressor | [43] |
| RCC | tumor suppressor | [42] | |
| ATC | tumor suppressor | [34] | |
| TRIM11 | PC | oncogene | [70] |
| OC | oncogene | [71] | |
| LC | oncogene | [72] | |
| HCC | oncogene | [73,74] | |
| TRIM14 | OS | oncogene | [41] |
| GC | oncogene | [60] | |
| CRC | oncogene | [59] | |
| GBM | oncogene | [58] | |
| TRIM15 | GADC | tumor suppressor | [89] |
| CRC | tumor suppressor | [90] | |
| TRIM16 | NB, LC, SC, BC | tumor suppressor | [63] |
| HCC | tumor suppressor | [65] | |
| OC | tumor suppressor | [64] | |
| TRIM23 | GC | oncogene | [75] |
| TRIM24 | CRC | oncogene | [76] |
| TRIM25 | CRC | oncogene | [77] |
| PC | oncogene | [78] | |
| GC | oncogene | [79] | |
| TRIM26 | HCC | tumor suppressor | [91] |
| TRIM27 | CRC | oncogene | [54] |
| IDC | oncogene | [55] | |
| OC | oncogene | [56,57] | |
| TRIM28 | GM | oncogene | [24] |
| PC | oncogene | [44] | |
| HCC | oncogene | [46] | |
| BC | oncogene | [45] | |
| TRIM29 | CRC | oncogene | [25] |
| NSCLC | oncogene | [50] | |
| LC | oncogene | [51] | |
| GC | oncogene | [52] | |
| SCC | tumor suppressor | [49] | |
| TRIM31 | HCC | oncogene | [80] |
| TRIM32 | LC | oncogene | [99] |
| GC | oncogene | [108] | |
| NB | tumor suppressor | [100] | |
| TRIM36 | PC | tumor suppressor | [92] |
| TRIM37 | GM | oncogene | [81] |
| TRIM44 | CRC | tumor suppressor | [101] |
| PTC | oncogene | [103] | |
| PC | oncogene | [105] | |
| BC | oncogene | [104] | |
| NSCLC | oncogene | [106] | |
| TGCT | oncogene | [107] | |
| HEC | oncogene | [102] | |
| TRIM45 | GM | tumor suppressor | [93] |
| TRIM47 | CRC | oncogene | [82] |
| PC | oncogene | [83] | |
| TRIM50 | HCC | tumor suppressor | [94] |
| TRIM52 | GM | tumor suppressor | [26] |
| OC | oncogene | [48] | |
| HCC | oncogene | [27] | |
| TRIM58 | LADC | tumor suppressor | [96] |
| CRC | tumor suppressor | [95] | |
| TRIM59 | NSCLC | oncogene | [29] |
| CCA | oncogene | [66] | |
| BC | oncogene | [67] | |
| EOC | oncogene | [109,110] | |
| RCC | oncogene | [69] | |
| Bca | oncogene | [111] | |
| CRC | oncogene | [68] | |
| OS | oncogene | [112] | |
| PC | oncogene | [113] | |
| CC | oncogene | [28] | |
| TRIM62 | AML | tumor suppressor | [97] |
| TRIM65 | UCB | oncogene | [84] |
| TRIM66 | OS | oncogene | [30] |
| NSCLC | oncogene | [61,62] | |
| TRIM68 | CRC | tumor suppressor | [31] |
| TRIM71 | NSCLC | oncogene | [85] |
ccRCC: clear cells renal carcinoma; CC: cervical cancer; HCC: hepatocellular carcinoma; GM: glioma; RCC: renal cell carcinoma; ATC: anaplastic thyroid carcinoma; PC: prostate cancer; OC: ovarian cancer; LC: lung cancer; OS: osteosarcoma; GC: gastric cancer; CRC: colorectal cancer; GBM: glioblastoma; GADC: gastric adenocarcinoma; NB: neuroblastoma; SC: skin cancer; BC: breast cancer; NSCLC: non-small cell lung carcinoma; IDC: intraductal carcinoma; SCC: squamous cell carcinoma; PTC: papillary thyroid cancer; TGCT: testicular germ cell tumor; HEC: human esophageal cancer; LADC: lung adenocarcinoma; CCA: cholangiocarcinoma; EOC: epithelyal ovarian cancer; Bca: bladder cancer; AML: acute myelod leukemia; UCB: bladder urothelial carcinoma).