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The primary structure and domain organization of human Casitas b-lineage lymphoma family proteins. c-Cbl, Cbl-b and Cbl-c proteins contain highly conserved tyrosine kinase-binding (TKB), linker (L), RING finger (RF) and proline-rich (PR) domains. 4H: Four-helix bundle; EF: EF hand, SH2: Src-homology 2; UBA: Ubiquitin-associated domain.
