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The Journal of Neuroscience logoLink to The Journal of Neuroscience
. 1983 Jul 1;3(7):1511–1519. doi: 10.1523/JNEUROSCI.03-07-01511.1983

Increase in nociceptive input to spinocervical tract neurons following chronic partial deafferentation

MJ Sedivec, J Ovelmen-Levitt, R Karp, LM Mendell
PMCID: PMC6564436  PMID: 6864259

Abstract

Recordings from antidromically identified spinocervical tract (SCT) cells in the partially deafferented spinal cord of chloralose- anesthetized cats have revealed reorganization of their input from peripheral receptors in the skin. Immediately after dorsal rhizotomy of segments L5, L6, S1, and S2, (sparing L7), units in L6 had a lower than normal probability of responding to moderate pressure, mechanical nociceptive, noxious heat, and cooling inputs. This persisted for about 6 weeks, after which normal or even larger than normal proportions of SCT units could be driven by these inputs. The proportion of units driven by hair deflection remained large throughout this period. Responses in the L7 segment with intact L7 dorsal root were unchanged. We suggest that afferent fibers from different receptor types differ in the extent of their normal functional projection, accounting for the selective changes after acute deafferentation. The chronic changes may reflect a differential ability of surviving afferent fibers to undergo compensatory changes in their projection (e.g., sprouting) after chronic rhizotomy.


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