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. Author manuscript; available in PMC: 2019 Aug 11.
Published in final edited form as: Oncogene. 2019 Feb 11;38(24):4700–4714. doi: 10.1038/s41388-019-0745-2

Figure 8. Schematic model of the role of KPNB1 in PCa progression.

Figure 8.

Dysregulation of KPNB1 in PCa facilitates the nuclear translocation of NF-κB p50, by which it can promote tumorigenesis and cell survival PCa cells. In addition, KPNB1-c-Myc positive feedback loop increases the expression level of Cyclin D1, Cyclin B1 and CDK1. The complex of Cyclin B1 and CDK1 can further enhances phosphorylation level of RCC1, by which it promotes PCa cell proliferation through accelerating cell cycle and mitosis.