Table 8.

Metabolites analyzed in urine and plasma after acute, short-term, or regular cocoa intake interventions, studied with non-targeted and targeted methodologies.

Type of Metabolite	Metabolites in Urine		Metabolites in Plasma (Targeted)
	Non-Targeted [55]	Targeted [57]	[57]	[58]
Polyphenols metabolites	(DHPV) 5-(3´,4´-dihydroxphenyl)-valerolactone sulfoglucuronide (HDHPVA) 4-hydroxy-5-(dihydroxyphenyl)-valeric acid glucuronide (HHMPVA) 4-hydroxy-5-(hydroxyl-methoxyphenyl)-valeric acid glucuronide (HHPVA) 4-hydroxy-5-(hydroxyphenyl)-valeric acid sulphate (HPV) hydroxyphenyl-valerolactone glucuronide (HPVA) 4-hydroxy-5-(phenyl)-valeric acidsulphate (MHPV) methoxyhydroxyphenyl valerolactone DHPV glucuronide (1) and (2) DHPV sulphate (epi) catechin glucuronide (epi) catechin sulphate HDHPVA HDHPVA sulphate HHPMVA sulphate HPV sulphate MHPV glucuronide Vanillic acid Vanillin sulphate	(-)-epicatechin 3-hydroxybenzoic acid 3-hydroxyhippuric acid 3-hydroxyphenyl acetic acid 3-hydroxyphenyl propionic acid 3-methoxy-4-hydroxyphenyl acetic acid 3,4-dihydroxyphenyl acetic acid 3,4-dihydroxyphenyl propionic acid4-hydroxybenzoic acid 4-hydroxyhippuric acid5-(3´,4´-dihydroxyphenyl)-γ-valerolactone 5-(3´-methoxy, 4´-hydroxyphenyl)-γ-valerolactone O-glucuronide 5-(3´-methoxy, 4´-hydroxyphenyl)-γ-valerolactone O-sulfate 5-(3´,4´-dihydroxyphenyl)-γ-valerolactone O-glucuronide isomers Caffeic acid Epicatechin-3´-O-glucuronide Epicatechin-7-O-glucuronide Epicatechin-O-glucuronide isomers Epicatechin-O-sulfate isomers Ferulic acidm-coumaric acidO-methyl-epicatechin-O-glucuronide isomersO-methyl-epicatechin-O-sulfate isomersp-coumaric acid Phenylacetic acid Protocatechuic acid Vanillic acid	3-hydroxyhippuric acid 3-hydroxyphenyl acetic acid 3-hydroxyphenyl propionic acid 3,4-dihydroxyphenyl acetic acid 3,4-dihydroxyphenyl propionic acid 4-hydroxybenzoic acid 4-hydroxyhippuric acid 5-(3´,4´-dihydroxyphenyl)-γ-valerolactone 5-(3´-methoxy, 4´-hydroxyphenyl)-γ-valerolactone O-glucuronide 5-(3´,4´-dihydroxyphenyl)-γ-valerolactone O-glucuronide (1) and (2) Caffeic acid Ferulic acid p-coumaric acid Phenylacetic acid Protocatechuic acid Vanillic acid	3´-O-methyl-(-)-epicatechin 4´-O-methyl-(-)-epicatechin Epicatechin
Purine metabolites	3-methyluric acid 3,7-dimethyluric acid 7-methylxanthine AMMU 1 and 2 (5) Theobromine Xanthine	-	-	-
Others	Aspartyl-phenylalanine Cyclo(aspartyl-phenylalanyl) Furoylglycine Methylglutaryl carnitine	-	-	-

Notes: (5) 1 and 2 correspond to isomers AMMU= 6-amino-5-[N-methylformylamino]-1-methyluracil.