Figure 7.
Examples of redox-responsive drug release. (A) Modification of both a viologen guest motif and a pillar[5]arene host resulted in a supramolecular amphiphile which self-assembles into vesicles. Control of encapsulated drug release was mediated by varying concentrations of redox triggers. Figure adapted with permission from reference 136. Copyright 2016 John Wiley and Sons. (B) A similar vesicle system made of self-assembling supramolecular amphiphiles was developed from host-guest complexation between polymers modified with β-cyclodextrin or a ferrocene guest, with drug release controlled by voltage-controlled redox of the ferrocene guest chemistry. Adapted with permission from reference 138. Copyright 2014 Royal Society of Chemistry.